martes, 20 de agosto de 2013

The evaluation of 1585 typhoid cases published between 1992-2011 in Turkey by pool analysis method

Purpose: Typhoid is a systemic infection caused by Salmonella enterica serovar typhi and it is still endemic in our country. Methods: Three national and two international databases were sought. The key words were determined as “tifo ve Türkiye” for national databases and “typhoid and Turkey” for international databases. Results: The data obtained from 1585 cases. Most common symptoms determined in patients were fever (85.1%), abdomen pain (63.7%), vomiting (30.4%), diarrhea (27.9%) and headache (22.8%). Most determined findings in physical examination were hepatomegaly (29.8%), splenomegaly (22.9%), relative bradycardia (17.6%), abdominal tenderness (13.6%) and abdominal distantion (12.3%). In 609 cases (35.3%),the diagnosis was established by isolating S.enterica serovar typhi in cultures performed from various materials. The most common used antibiotics in treatment were ceftriaxone (40.1%), ciprofloxacin (34.3%) and chloramphenicol (15.8%). Most common complications in the examined cases were intestine perforation (29.4%), hepatitis (1.8%) and pneumonia (1.8%). Conclusion: Typhoid is diagnosed in Turkey mainly by clinical signs and treatment is carried out empirically. Ceftriaxone and ciprofloxacin are the predominantly used medicines. Though there are no serious problems with these drugs in Turkey, resilient cases are reported in various regions of the world. Protection of people are essential for controlling of typhoid fever in endemic areas.

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