martes, 20 de agosto de 2013

Further Research needed to understand the role of H2S as a biological mediator and therapeutic potential

In contrast to its role as poison, hydrogen sulfide (H2S) is now considered as the third gaso transmitter after nitric oxide (NO) and carbon monoxide (CO) [1,2,3]. Though it was first reported in 1982 that they are produced in mammalian tissues, but it is only now emerged as a mediator of important physiologic functions in humans [4]. In the central nervous system (CNS), H2S functions not only as a neuro-modulator, but also as a neuro-protectant against oxidative stress[5]. In the cardiovascular system, H2S relaxes vascular smooth muscles by the activation of KATP channels and inhibits smooth muscle cell proliferation via the mitogen-activated protein kinase signaling pathway [6]. These effects are important for maintaining normal blood pressure and preventing vessel structural remodeling, and identifies [7, 8, 9, 10]. H2S as an important factor in controlling the progression of some vascular diseases, such as hypertension®.

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