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jueves, 1 de agosto de 2013

Fosfomycin Trometamol in Patients with Renal Insufficiency and in the Elderly

Single oral dose therapy with fosfomycin trometamol (FT) 3 g is recommended in the treatment of uncomplicated urinary tract infection (UTI) not only in premenopausal, but also in postmenopausal elderly, otherwise healthy women. It can also be used as reapplication every 10 days for prophylaxis of recurrent uncomplicated cystitis. FT 3 g has also been used with two oral doses of 3 g (on two consecutive days) for perioperative prophylaxis in transurethral interventions or with three doses (every other day, three times) for treatment of complicated lower UTI including many elderly patients. The tolerance and safety in the patients above 65 years of age did not differ from younger ones. Therefore, there is also an indication to administer oral FT 3g in adults above 65 years of age for treatment or prophylaxis of uncomplicated UTI. Patients with renal insufficiency up to a creatinine clearance of 20 ml/min can be expected to have still sufficiently high urinary concentrations of fosfomycin, that treatment of cystitis should be justified from pharmacokinetic/pharmacodynamic point of view. From preliminary clinical results there is also an indication to use oral FT 3 g in adults with renal insufficiency up to a creatinine clearance of 20 ml/ min, with single dose for treatment of lower uncomplicated UTI with otherwise normal urinary tract or with repeated doses (every second or third day according to the degree of renal insufficiency) for treatment of lower complicated UTI caused by fosfomycin susceptible pathogens resistant to other oral antimicrobial drugs.http://www.scribd.com/doc/84360452/Fosfomycin-Trometamol-in-Patients-with-Renal-Insufficiency-and-in-the-Elderly http://www.scribd.com/iMedPub



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