jueves, 1 de agosto de 2013

Antimicrobial And Spermicidal Activity Of Native And Recombinant Pediocin Cp2: A Comparative Evaluation

Bacteriocins produced by lactic acid bacteria (LAB) are extremely attractive dual-acting candidates for formulating topical personal care products aimed at contraception and prophylaxis and treatment of bacterial vaginosis (BV). “Generally recognized as safe” lactic acid bacteria synthesize these antimicrobial bacteriocins as components of their natural defense system. These are extremely versatile agents as they could be used as spermicidal agents to not only prevent unwanted pregnancy but also to combat the growing prevalence of sexually transmitted microbial infections and viral diseases. Probiotic LAB have also been well documented as being effective in biotherapeutic applications against gastrointestinal pathogens, e.g. Clostridium, Helicobacter pylori, Salmonella, Escherichia coli, Listeria monocytogenes, and rotaviruses. Therapeutic application of probiotic strains to protect against gastrointestinal infections may be of great importance for future medicinal use.

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